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Gray Matter Averaging and Statistical Comparisons of Gray Matter Distribution
Statistical map of average gray matter loss in AD (n = 46). Based on averaging and comparing gray matter measurements across equivalent regions of cortex in all 46 subjects, this statistical field reflects whether the average gray matter is reduced in patients (average of 26 subjects) relative to controls (average of 20 subjects). The significance of this reduction at each cortical location is shown. Severe, more localized reductions are visualized in the temporal lobe and temporo-parietal cortex. This profile of gray matter loss mirrors the anatomical distribution of early perfusion deficits and metabolic change in mild to moderate AD.
MIT scientists have found a new way to monitor Alzheimer's disease using a fluorescent marker (“bubbles” in the background). The dye enters the brain after an intravenous injection and selectively binds to the plaques associated with the disease. Subsequent scanning with a near-infrared laser beam (hv) makes it possible to monitor the plaques through the characteristic fluorescence of the dye (black circle). (Image courtesy of Evgueni Nesterov)
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